SDSU Research Foundation Postdoctoral Research Fellow in San Diego, California
This posting is open until filled with a first review on 8/28/20.
The Sohl Lab at San Diego State University in San Diego, CA is interested in probing the role of metabolic enzymes in the development of cancer, with focus on structure/function consequences of enzyme mutations, organelle-specific effects of altered enzyme activity, and the role of tumor cell environments on enzyme regulation. Enzymes of interest include isocitrate dehydrogenases and malate dehydrogenases, both of which have been implicated in a variety of cancers. We use a wide range of tools from enzyme kinetics to cell-based assays, and engage in collaborative work to address interests in metabolomics and lipidomics both in vitro and in vivo. Funding sources for our lab include an NIGMS R35 award and an American Cancer Society Research Scholar grant. The PI is committed to supporting the development of the postdoctoral scientist for their next steps in their scientific career, both at and beyond the bench. For more information on our lab, including recent publications, please visit https://sohl-lab.sdsu.edu/
We are seeking to hire a postdoctoral scientist to help advance our work on understanding how isocitrate dehydrogenase (IDH) drives cancer. The successful candidate will lead a project on determining the organelle-specific consequences of cancer-relevant IDH1 mutations, and how alterations in organelle-specific pathways are communicated to other locations within the cell. The ideal candidate will have completed their PhD, and is a motivated, collaborative, ambitious, creative, and detail-oriented individual. We are interested in independent, enthusiastic, and creative scientists that value collaboration in a diverse and enthusiastic lab environment. Our lab recognizes that we are at our best and most creative when we represent a diverse group of scientists, so we encourage applications from under-tapped talent pools.
Candidates need to submit a cover letter briefly detailing their current research and how their work fits in with Sohl Lab research project(s), a CV, and full contact information for at least three references.
The Postdoctoral scientist is responsible for but not limited to:
Generating cell culture lines
Performing cellular assays and imaging
Biochemical, molecular biology, and cell biology assays
Data analysis and communication, 15%
Processing data generated from bench work activities
Processing lipidomic and metabolomic data
Professional development, 10%
Engaging in the opportunities and experiences that are required for the candidate to successfully transition to the next stage in their scientific career
Mentoring graduate and undergraduate students
Attending seminars, conferences, and other scientific educational opportunities
Writing fellowships (e.g. F32, K99, AACR, etc.)
PhD in cancer biology, molecular biology, biochemistry, cell biology, or related field.
Experience in molecular cell biology, basic cancer biology, and biochemistry.
Expertise in mammalian cell culture techniques including generation of cell lines and assays assessing basic cancer phenotypes (migration, proliferation, etc.).
Experience in microscopy and cell imaging techniques (fluorescence microscopy).
Experience in mining and extracting TCGA data.
Experience in organelle purification.
Experience in modern molecular biology and biochemistry techniques (protein purification, cloning, immunohistochemistry).
Demonstrated track record of publications in peer-reviewed journals.
A background check (including a criminal records check) must be completed satisfactorily before any candidate can be offered a position with SDSU Research Foundation
San Diego State University Research Foundation is an EEO/AA/Disability/Vets Employer
Req No.: 2020-10799
Starting Salary: 4,506.67/Mo.
External Company URL: www.sdsu.edu
Street: 5500 Campanile Drive
Is this position teleworking?: Yes